I think the Dunedain suffered from a plague in the second age and Turin's little sister Lalaith dies from plague, in children of Hurin, very sad.
Yes, the Evil Breath was a wind that brought a plague out of Angband in the autumn of First Age 469. Túrin's sister Lalaith was indeed one of its victims.
The middle of the Third Age saw the Great Plague that swept through Middle-earth in the years 1635 to 1637. As told at Tolkien Gateway:
The Great Plague began in the east beyond Mordor and hit Rhûn and Rhovanion, and after it had passed, more than half the folk of the Kingdom of Rhovanion had been killed. The Plague also hit the enemies of Gondor, otherwise they could overwhelm the weakened kingdom easily, but this didn't affect Sauron, who could wait.
It first reached Gondor in T.A. 1636 (just a couple of years after King Minardil had been killed at Pelargir by the Corsairs of Umbar). The Plague was devastating in Gondor; Osgiliath was especially hit hard, suffering the highest casualties outside of Rhovanion. Many fled the city and removed to Ithilien and Anórien, and Minas Anor became the King's seat. The casualties were so high that the fortresses guarding Mordor were abandoned as the troops were recalled. The new king, Telemnar was killed together with his kin, followed by the White Tree of Gondor, as well as many others of the Dúnedain; two centuries after the Kin-strife, this further destroyed the people of Gondor.
From there the plague spread west and then north, making Eriador desolate. Dunland suffered less from the Plague than most due to their self-isolation. However, the Plague regained strength as it went north, and Minhiriath (the southern part of Cardolan) was especially hit hard. The joint garrison (of the North and South Kingdoms) at Tharbad ceases to exist. The last of the Dúnedain of Cardolan died on the Barrow-downs, and evil spirits from Angmar and Rhudaur entered the realm.
While the Shire suffered greatly, the plague lessened passing northward until the northern part of Arthedain was scarcely affected. Arthedain still defended Fornost Erain to the north.